Promethazine is the first generation antihistamine of a nervous system and phenothiazine family. Drugs are strong branches and weak psychological effects. It has decreased motion obstruction and has antiemetic (Histamine H1 receptor but it does not block the production of histamine) and anticholinergic properties. In some countries, it is indicated for insomnia when benzodiazepines are ineffective. It is available in many countries under many brand names. Promoting a group of scientists from the Rana-Palenik laboratory in the mid-1940s, it was able to synthesize phenothiazine.


Prometheus Hydro Chloride is a resmatic compound.

Promethazine hydrochloride is a chemically nominated as phenothiazine derivative, 10H-Phenothiazine-10-ethanamine, n, n, α-trimethyl-, monohydrochloride, (± )- with the following structural formula:


C17H20N2S•HCl           M.W.320.88

Primitive Hydrochloride is yellow, emitted, crystalline powder, which gradually becomes blurred in oxidation and chronic exposure to the air. It is water-soluble and alcohol-free soluble.

For oral administration, each tablet contains 25 milligrams or 50 milligrams of Prometheus Hydrochloride. In addition, each tablet has the following inactive components: Dbic calcium phosphate, magnesium stearate, microcosstyle cellulose, sodium starch gaollet and steroid acid.

The brochure Hydrochloride tablet contains USP, 50 milligrams anniversary lactose.

Promethazine is a prescription drug. It comes as an oral tablet, an oral solution, an injection solution and a rectal suppository.

Promethazine oral tablets are only available as a generic drug. Generic drugs typically cost less than the brand-name version.


  1. Promethazine oral tablets are only available as a generic drug. This is not a brand-name version.
  2. The Promethazine comes in four forms: oral tablets, oral solutions, injectable solutions, and rectal suppository.
  3. Promethazine oral tablets are used in various conditions such as allergies, obesity, nausea, vomiting, anxiety disorders prior to surgery, and surgical post-operative pain. It is used for a sleep support before and after the surgery.

Promethazine Medical Uses:

Promethazine is used for most conditions, such as allergies, movements, nausea and vomiting, anxiety before surgery and pain after surgery. It is used for a sleep support before and after the surgery.

This drug can be used as part of a combination therapy. This means that you may need to take it with other medications.

  • As a sedative
  • For preoperative seasons and to counter postnarcotic pronunciation
  • Due to psychological conditions, frequent density, unrest, and movement (mainly used in Europe for this purpose).
  • For dealing with heart fever (allergic rhinitis), etc., as analogue medications, or allergic reactions, alone or oral diagentants such as cuddiefferine control in combination.
  • As a beneficial treatment for anaphylaxoid conditions (IM / IV Root Priority).
  • In the UK, promethazine is the first choice drug, preferred as an old drug with which to experience the second use of the big-line metoclopramide or prochlorperazine, with moderate to serious morning sickness and hyperemesis gravidarum.
  • Previously, it was used as an anticyclone, although it is usually not directed for this purpose; Promethejen is only about 1/10 of the antipsychotic energy of chlorpromazine.
  • Treatment for a migraine; However, other similar medications, such as magazines, have shown to have more favorable treatment profile, and are used almost exclusively on promethazine.

How it works:

Promethazine belongs to a class of drugs called snithazine. A group of medicines is a group of drugs that work similarly. This drug is often used to treat similar conditions.

Promethazine works to prevent the release of a substance called histamine from specific cells in your body. Generally, when you are becoming allergic, the histamine is usually released when it is exposed to pollen, currents, mold or chemical substances.

With the release of the hostum, this drug helps with mute and pain control. This helps to control the awakening of the histamine and helps you to be careful and increase your senses.

This drug reduces your brain’s brain stimuli which send signals to your vomiting.

Promethazine Side effects:

Some documented side effects include:

  • This drug may cause extreme thirst. It may be another side effect.
  • Tardive dyskinesia (effects due to dopamine D2 receptor antagonism)
  • Confusion in the elderly
  • Drowsiness, dizziness, fatigue, more rarely vertigo
  • Dry mouth
  • Respiratory depression in patients under age of two and in those with severely compromised pulmonary function
  • Constipation
  • Chest discomfort/pressure (typically in cases when the patient is already taking medication for high blood pressure)
  • Akathisia
  • Paresthesia
  • Short temper/irritability

Extremely rare side effects include:

  • Seizures
  • Neuroleptic malignant syndrome
  • Euphoria (very rare, except with high IV doses and/or coadministration with opioids/CNS depressants)

More common side effects:

  • drowsiness
  • changes in blood pressure
  • allergic skin reactions
  • reduced platelet counts
  • reduced white blood cell production
  • breathing problems
  • increased excitability
  • abnormal movements

The possible reason for the more serious side effects is to avoid aging on this drug list. In many countries (including the United States and the UK), promethazine is contraindicated among children under the age of two and is strongly due to problems with warning between children in two to six, respiratory depression and sleep apnea.

Prostasteni is listed as one of the highest anticolin ergic activity drugs in the long-term cognitive disorder with the anticoagulant load.

Promethazine Pharmacology:

Promethazine, a phenothiazine derivative, is similar but structurally different from neuroleptic phenothiazines with different effects. It primarily acts as a strong antagonist of the H1 receptor (Antihistamine) and a moderate mac receptor antigenic (Anticholinergic) and has  5-HT2A, 5-HT2C, D2, and α1-adrenergic receptors, Where it works as an opponent on all sites.

Another prominent use of publicity as a local analytics, sodium channels are blocked.

Promethazine History:

Promethazine was first synthesized by Rhone-Poulenc (later became part of Sanofi) by a group led by Paul Cherpenia in the early 1940’s. The team was working to improve Defenidine; Medical chemistry led to the creation of the same line chlorpromazine.






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